Starting in 2002, pianist and composer Melissa St. Pierre has toured the United States both solo and with ensembles. Specializing in prepared piano work of John Cage, St. Pierre has used those pieces as a jumping-off point into her own prepared piano work utilizing live electronic manipulation.

In her self-described style of comprovisation, St. Pierre took composition courses at Bennington College with Steven Siegel, Amy Williams, Kitty Brazelton, Allen Shawn, Erik Lundborg and Joel Chadabe, piano with John Van Buskirk and later with Doris Steveson and Kathy Supove, improvisation with Charles Gayle and Milford Graves, as well as many master classes in piano and improvisation, most notably with William Parker and Elliot Sharp. In 2002, she received the Woolley Grant in Music to study Contemporary Piano Performance at New England Conservatory with Steve Drury, which lead to an invitation to perform at the 50th Anniversary of the writing of Cage's 4'33" at the Under the Influences Festival opening for DJ Spooky  in Asheville, NC, and a full recital of Sonatas and Interludes for a prepared nine-foot steinway at Saltworks Gallery in Atlanta, GA.

St. Pierre played briefly in the indie rock group Bat Eats Plastic in New York City in 2003, making appearances at such fine venues as Tonic in Lower Manhattan and *asterisk art and music space in Bushwick, Brooklyn. In their first recorded output together, Millie Benson of Heroin God Music and Dave McClelland of the influential Ohio hardcore band Craw joined St. Pierre in creating an unbroken 25-minute piece for two guitars, vocals and prepared piano inspired by the graphic notational scores and music of Anthony Braxton.

Upon moving to the Berkshire hills of Massachusetts in 2004, St. Pierre took up her "punk rock cabaret act under the moniker "Invading Posh Places to Warp Your Faces" at local four-star hotel bars, toured it to Goodbye Blue Monday in Brooklyn and Eleven Restaurant located in the complex that also houses the Massachusetts Museum of Contemporary Art, where she at the same time became the programmer of Indie Rock Night, a weekly curated music event hosting such non-indie musicians as Parts and Labor and Japanther.

Upon graduating form Bennington College in 2005, began to delve into installation art with Adam Zaretsky, performative time-based art pieces with Barbara Groves and high concept art modeling for photographers such as Gregory Crewdson and Domingos Goncalves. At this time, she also began curating noise artists like Carlos Giffoni and Burning Graveyards at the Storefront Artist Project. The following year was spent investigating new techniques on prepared piano in a small cottage in Provincetown, MA on the coast, and writing a new and as-yet untitled series of miniatures for prepared piano.

Upon the commitment in mid-2007 of avant music label Table of the Elements to release St. Pierre's debut 16-minute 8-track instrumental EP Specimens, St. Pierre began collaborating and with bands such as Collections of Colonies of Bees from Milwaukee, WI 2007 and Megafaun from Raleigh-Durham, NC and Arnold Dreyblatt from Berlin, DE in 2008, playing the Middle East in Boston, the Knitting Factory in Manhattan, and Salem Art Works, an art farm and residency space in upstate NY.

That year brought more collaborations and touring for St. Pierre, beginning with a Table of the Elements showcase at South By Southwest. In October 2008, she bridged the continental divide for the first time and debuted several new solo works on prepared piano at the BBMix Festival in Boulgne-Billancourt, FR, on the outskirts of Paris at the venue Carré Bellefiuelle opening for Why?, and label-mates David Grubbs and Richard Youngs. In another first, St. Pierre began using computers in her work on the behest of soon-to-be and now current collaborator Jesse Stiles. Playing the Fantastic Voyagers Festival and Future Tenant with Spain's Mattin in her current place of residence of Pittsburgh, PA, as well as the ISSUE Project Room in Brooklyn, NY, Stiles + St. Pierre have been greeted by much applause from underground communities.

In 2009, St. Pierre continued her solo work while also keeping up Technizal Drawings. In March, she oncertized the Sonatas and Interludes for the first time in seven years nearly to the date at the ISSUE Project  Room, and is looking forward to completing a commission for Oberlin's WAM! Ensemble premiering in early May, opening for Momus at the Iron Horse Music Hall later that month, touring Europe as a solo performer under the direction of Julie Tippex Agency in Berlin for the month of June with stops at the Golden Pudel Club collaborating with Augsburger Tafelconfect and an open-air concert in the HafenCity with Ensemble Integrales in Hamburg, DE as well as the Terra Trema Festival in Cherbourg, FR and La Malterie in Lille.